Histamine liberation by cotton dust extracts: evidence against its causation by bacterial endotoxins.
نویسنده
چکیده
The recently stated hypothesis that histamine liberation by cotton dust extracts is caused by endotoxins from gram-negative bacteria contained in cotton was studied experimentally in various animals. It was shown clearly that such amounts of endotoxin as were found in cotton dust did not give rise to histamine liberation which was provoked by extracts from cotton card-room dusts. Further arguments are given which testify against the endotoxin hypothesis.
منابع مشابه
[Studies on cotton dust in relation to Byssinosis].
The clinical features of byssinosis which have suggested an allergic factor in its aetiology have been discussed in an earlier paper (Furness and Maitland, 1952). Prausnitz (1936) concluded, on the basis of a wheal and flare type of skin reaction elicited by injecting extracts of cotton dust, that he had demonstrated hypersensitivity specific to byssinosis and supported this view with collatera...
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Previous reports suggest that byssinosis, an asthma-like condition among textile workers, may be mediated in part by histamine liberated following inhalation of dust. A simple, sensitive, and reliable procedure using pig platelets which contain the unusually high concentration of 0.8-1.6 microgram histamine/10(9) cells has been devised for the assay of histamine-releasing factors in cotton mill...
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ورودعنوان ژورنال:
- British journal of industrial medicine
دوره 18 شماره
صفحات -
تاریخ انتشار 1961